There are, I suppose, few places even on the East Coast of England more lonely and remote than the village of Little Sundersley and the country that surrounds it. Far from any railway, and some miles distant from any considerable town, it remains an outpost of civilization, in which primitive manners and customs and old-world tradition linger on into an age that has elsewhere forgotten them. In the summer, it is true, a small contingent of visitors, adventurous in spirit, though mostly of sedate and solitary habits, make their appearance to swell its meagre population, and impart to the wide stretches of smooth sand that fringe its shores a fleeting air of life and sober gaiety; but in late September-the season of the year in which I made its acquaintance-its pasture-lands lie desolate, the rugged paths along the cliffs are seldom trodden by human foot, and the sands are a desert waste on which, for days together, no footprint appears save that left by some passing sea-bird. I had been assured by my medical agent, Mr. Turcival, that I should find the practice of which I was now taking charge "an exceedingly soft billet, and suitable for a studious man;" and certainly he had not misled me, for the patients were, in fact, so few that I was quite concerned for my principal, and rather dull for want of work. Hence, when my friend John Thorndyke, the well-known medico-legal expert, proposed to come down and stay with me for a weekend and perhaps a few days beyond, I hailed the proposal with delight, and welcomed him with open arms.
Vitamin A (retinol) is an essential dietary compound with myriad metabolic and regulatory functions. Deficiency can result in vision problems, compromised immune responses, and a host of other medical issues. More than 600 carotenoids have been identified in plants, algae, fungi, and bacteria, and around 50 carotenoids-including ÃŸ-carotene-can be converted into vitamin A. Carotenoids and Vitamin A in Translational Medicine reviews the medical use of carotenoids and vitamin A in cancer; diseases of the skin, eye, ear, and lung; and inflammatory bowel and metabolic diseases. It also discusses the analytics of carotenoids and the supply of carotenoids and vitamin A in developing countries.
Serving a broad community of researchers and practitioners conducting basic and clinical analysis on carotenoids and vitamin A for medical purposes, the book evaluates basic research, epidemiological studies, and clinical trials in the field. It updates information on the worldwide problem of vitamin A deficiency and discusses extensively the pros and cons of carotenoid supplementation in cancer. The authors provide a comprehensive overview of the efforts made in the field of carotenoid research with respect to translational medicine and present the future outlook on carotenoids as new therapeutic agents.
It is the editors' intent through the contributions in this volume to expand this important discussion on therapeutic approaches using carotenoids and retinoids. In doing so, they hope to enhance the quality of research which brings safe, effective, and clinically proven medicines to patients.
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